Basic Information
| ID | DRAMP00032 |
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| Sequence | GNGVLKTISHECNMNTWQFLFTCC |
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| Length | 24 |
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| Name | Ruminococcin A (RumA; Bacteriocin) |
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| Source | Ruminococcus gnavus & Ruminococcus hansenii (Gram-positive bacteria) |
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| Activity | Antimicrobial, Antibacterial, Anti-Gram+ |
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| Pathogen | Gram-positive bacteria: Bifidobacterium longum (strain: ATCC 15707) (MIC=75 µg/ml), Bacillus cereus (strain: Z4222, TZ415) (MIC=75 µg/ml), Eubacterium contortum (strain: ATCC 25540) (MIC=32.5 µg/ml), Ruminococcus obeum (strain: ATCC 29174) (MIC=32.5 µg/ml), R. gnavus (strain: ATCC 29149) (MIC=75 µg/ml), Clostridium perfringens (strain: CpA) (MIC=75 µg/ml), Clostridium difficile serogroup A (strain: B-1) (MIC=75 µg/ml), C. difficile serogroup C (strain: C253) (MIC=75 µg/ml), C. difficile serogroup S3 (strain: 79685) (MIC=75 µg/ml), C. botulinum type A (strain: CIP 38) (MIC=75 µg/ml), C. botulinum type B (strain: NCTC 7273) (MIC=75 µg/ml), C. botulinum type E (strain: NCTC 8266) (MIC=75 µg/ml), C. bifermentans (strain: NCTC 506) (MIC=75 µg/ml). |
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| Hemolytic Activity | No hemolysis information or data found in the reference(s) presented in this entry |
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| Cytotoxicity | No cytotoxicity information found |
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| N-terminal Modification | Free |
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| C-terminal Modification | Cyclization (possibly) |
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| Linear/Cyclic/Branched | Cyclic (very possibly) |
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| Uniprot |
P83674, P83676, P83677, Q8VLK0, Q9K381, P83675, P83679, P83680, Q8VLK0 |
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| PDB |
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| 3D View | |
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| PDB Download | Download PDB Predicted by Alphafold2 |
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| PubMed ID | 11526013, 11741840, 12089024 |
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