Basic Information

IDDRAMP00222
SequenceGETDPNTQLLNDLGNNMAWGAALGAPGGLGSAALGAAGGALQTVGQGLIDHGPVNVFIPVLIGPSWNGSGSGYNSATSSSGSGS
Length84
NameMicrocin E492 (MccE492; Bacteriocin)
SourceKlebsiella pneumoniae RYC492 (Gram-negative bacteria)
ActivityAntimicrobial, Antibacterial, Anti-Gram-
PathogenGram-negative bacteria: Escherichia coli F (MIC=0.14 µM), Escherichia coli 363 (MIC=0.02 µM), Escherichia coli ML35p (MIC=0.14 µM), Escherichia coli GM1 (MIC=0.04 µM), Escherichia coli GM1 KP1060(MIC=0.65 µM), Escherichia coli W3110 (MIC=0.02 µM), Escherichia coli W3110-KP1344 Pms7 (MIC=0.08 µM), Escherichia coli W3110-6 (MIC=0.32 µM), Escherichia coli C600 (MIC=0.08 µM), Escherichia coli C600 pHX405 (MIC=0.16 µM), Salmonella enteritidis (MIC=0.6 µM), Salmonella typhimurium (MIC=1.2 µM).
Hemolytic ActivityNo hemolysis information or data found in the reference(s) presented in this entry
CytotoxicityNo cytotoxicity information found
N-terminal ModificationFree
C-terminal ModificationAttachment to a siderophore ester
Linear/Cyclic/BranchedLinear
Uniprot Q9Z4N4
PDB
3D View
PDB DownloadDownload PDB Predicted by Alphafold2
PubMed ID12890026, 15102848, 7682973

Physicochemical Properties

Residues84
SequenceGETDPNTQLLNDLGNNMAWGAALGAPGGLGSAALGAAGGALQTVGQGLIDHGPVNVFIPVLIGPSWNGSGSGYNSATSSSGSGS
Molecular Weight7936.533
Grand Average of Hydropathy0.065
Isoelectric Point4.05
Charge at pH 7.4-4.406
Secondary StructureHelix: 0.238, Turn: 0.488, Sheet: 0.250
Instability Index18.913
Aromaticity0.048

Similar Structure Search

Candidates based on structure

Address: No.2699 Qianjin Street, Changchun City, China. Zip Code: 130012. 苏ICP备2021057230号-1.