Basic Information
| ID | DRAMP00856 |
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| Sequence | GLPVCGETCVGGTCNTPGCTCSWPVCTRN |
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| Length | 29 |
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| Name | Kalata-B1 (Plant defensin) |
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| Source | Oldenlandia affinis |
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| Activity | Antimicrobial, Antibacterial, Anti-Gram+, Anti-Gram-, Antifungal, Antiviral |
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| Pathogen | [Ref.10430870]Gram-positive bacterium: Staphylococcus aureus (MIC=0.26 µM), Micrococcus luteus (MIC=40.4 µM);##Gram-negative bacterium: Klebsiella oxytoca (MIC=54.8 µM);##Fungi: Candida kefyr (MIC=21.4 µM).##[Ref.18008336]Virus:HIV:inhibition the cytopathic effects of HIV-1 infection in cultured human T-lymphoblast (CEM-SS) cells(EC50=140 nM). |
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| Hemolytic Activity | [Ref.12779323] HD50 = 300 μM against Human type A red blood cells. |
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| Cytotoxicity | [Ref.18008336]CEM-SS cells:IC50=3500 nM. |
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| N-terminal Modification | Cyclization (N termini to C termini) |
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| C-terminal Modification | Cyclization (C termini to N termini) |
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| Linear/Cyclic/Branched | Cyclic |
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| Uniprot |
P56254 |
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| PDB |
2KHB |
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| 3D View | |
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| PDB Download | Download PDB Predicted by Alphafold2 |
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| PubMed ID | 18008336, 10430870, 7703226, 17534989, 23129773 |
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