Basic Information
| ID | DRAMP01064 |
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| Sequence | AWKLFDDGV |
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| Length | 9 |
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| Name | Anticancerous peptide 1 (Cr-ACP1; Plants) |
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| Source | Cycas revoluta (Sago palm) |
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| Activity | Antimicrobial, Antibacterial, Anti-Gram+, Anti-Gram-, Anti-cancer |
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| Pathogen | [Ref.21882228]Gram-positive bacteria: Staphylococcus epidermidis (MIC=60 µM), Bacillus subtilis (MIC=30 µM);##Gram-negative bacteria: Pseudomonas aeruginosa (MIC=30 µM), EEscherichia coli strain ATCC 8739 (MIC=30 µM). |
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| Hemolytic Activity | [Ref.21882228] Hemocompatibility study revealed the effectiveness of both the peptides where it showed no significant lysis of normal RBC cells compare to positive control (Triton X-100). Cr-ACP1 induced hemolysis of 7% at the conentration of 1 mM. |
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| Cytotoxicity | [Ref.21882228] IC50 = 1.5 mM in Hep2 (Human epidermoid cancer cells); IC50 = 0.9 mM in HCT15 (human colon carcinoma cells HCT15); Cr-ACP1 induced a cell viability of 66% at the concentration of 4 mM. |
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| N-terminal Modification | Free |
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| C-terminal Modification | Free |
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| Linear/Cyclic/Branched | Linear |
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| Uniprot |
B3EWE7 |
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| PDB |
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| 3D View | |
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| PDB Download | Download PDB Predicted by Alphafold2 |
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| PubMed ID | 21882228 |
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