Basic Information

IDDRAMP01108
SequenceGIGTKILGGVKTALKGALKELASTYVN
Length27
NameMaximin-2 (Toads, amphibians, animals)
SourceBombina maxima (Giant fire-bellied toad) (Chinese red belly toad)
ActivityAntimicrobial, Antibacterial, Anti-Gram+, Anti-Gram-, Antifungal
Pathogen[Ref.11835991] Gram-negative bacteria: Escherichia coli ATCC 25922 (MIC=19.5 µg/ml), Klebsiella pneumoniae (MIC=9 µg/ml);##Gram-positive bacteria: Staphylococcus aureus ATCC 2592 (MIC=19.5 µg/ml), Bacillus pyocyaneus CMCCB 10104 (MIC=19.5 µg/ml), Bacillus megatherium (MIC=19.5 µg/ml), Bacillus dysenteriae (MIC=2.7 µg/ml);##Yeast: Candida albicans ATCC 2002 (MIC=3 µg/ml).
Hemolytic Activity[Ref:11835991]Little hemolytic activity at 50 μg/ml against red blood cells
CytotoxicityNot included yet
N-terminal ModificationNot included yet
C-terminal ModificationNot included yet
Linear/Cyclic/BranchedNot included yet
Uniprot P83081, P83086, Q58T49
PDB
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PDB DownloadDownload PDB Predicted by Alphafold2
PubMed ID15770703, 11835991

Physicochemical Properties

Residues27
SequenceGIGTKILGGVKTALKGALKELASTYVN
Molecular Weight2703.181
Grand Average of Hydropathy0.341
Isoelectric Point9.826
Charge at pH 7.42.546
Secondary StructureHelix: 0.333, Turn: 0.259, Sheet: 0.296
Instability Index-1.744
Aromaticity0.037

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