Basic Information
| ID | DRAMP01110 |
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| Sequence | GIGGVLLSAGKAALKGLAKVLAEKYAN |
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| Length | 27 |
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| Name | Maximin-4 (Toads, amphibians, animals) |
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| Source | Bombina maxima (Giant fire-bellied toad) (Chinese red belly toad) |
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| Activity | Antimicrobial, Antibacterial, Anti-Gram+, Anti-Gram-, Antifungal, Antiviral, Anti-cancer |
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| Pathogen | [Ref.11835991] Gram-negative bacteria: Escherichia coli ATCC 25922 (MIC=2.7 µg/ml), Klebsiella pneumoniae (MIC=15 µg/ml);##Gram-positive bacteria: Staphylococcus aureus ATCC 2592 (MIC=2.7 µg/ml), Bacillus pyocyaneus CMCCB 10104 (MIC=2.7 µg/ml), Bacillus megatherium (MIC=1.5 µg/ml), Bacillus dysenteriae (MIC=2.7 µg/ml);##Yeast: Candida albicans ATCC 2002 (MIC=15 µg/ml);##Virus: HIV-1 (IC50=24.2 µg/ml, EC50=21.9 µg/ml);##Cancer cell lines: C8166 (IC50=24.2 µg/ml), Molt-4 (IC50=35.4 µg/ml). |
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| Hemolytic Activity | [Ref:11835991]Little hemolytic activity at 50 μg/ml against red blood cells |
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| Cytotoxicity | Not included yet |
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| N-terminal Modification | Not included yet |
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| C-terminal Modification | Not included yet |
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| Linear/Cyclic/Branched | Not included yet |
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| Uniprot |
P83083, Q58T42, Q58T44, Q58T52, Q58T62, Q58T77, Q58T79 |
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| PDB |
2MHW resolved by NMR |
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| 3D View | |
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| PDB Download | Download PDB Predicted by Alphafold2 |
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| PubMed ID | 15770703, 11835991 |
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