Basic Information

IDDRAMP01163
SequenceTRSSRAGLQFPVGRVHRLLRK
Length21
NameBuforin-2 (Buforin II; Fragment of Histone H2A; toads, amphibians, animals)
SourceBufo gargarizans (Asian toad) (Bufo bufo gargarizans)
ActivityAntimicrobial, Antibacterial, Anti-Gram+, Anti-Gram-, Antifungal
PathogenGram-positive bacteria: Bacillus subtilis (MIC=2 µg/ml), Staphylococcus aureus (MIC=4 µg/ml), Streptococcus mutans (MIC=2 µg/ml), Streptococcus pneumoniae (MIC=4 µg/ml), Pseudomonas putida (MIC=2 µg/ml);##Gram-negative bacteria: Escherichia coli (MIC=4 µg/ml), Salmonella typhimurium (MIC=1 µg/ml), Serratia sp. (MIC=4 µg/ml).##Fungi: Candida albicans (MIC=1 µg/ml), Cryptococcus neoformans (MIC=1 µg/ml), Saccharomyces cerevisiae (MIC=1 µg/ml).
Hemolytic ActivityNo hemolysis information or data found in the reference(s) presented in this entry
CytotoxicityNo cytotoxicity information found
N-terminal ModificationFree
C-terminal ModificationFree
Linear/Cyclic/BranchedLinear
Uniprot P0DQL2
PDB
3D View
PDB DownloadDownload PDB Predicted by Alphafold2
PubMed ID8573171, 8946958

Physicochemical Properties

Residues21
SequenceTRSSRAGLQFPVGRVHRLLRK
Molecular Weight2434.847
Grand Average of Hydropathy-0.638
Isoelectric Point12
Charge at pH 7.45.242
Secondary StructureHelix: 0.286, Turn: 0.238, Sheet: 0.190
Instability Index84.195
Aromaticity0.048

Similar Structure Search

Candidates based on structure

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