Basic Information

IDDRAMP01319
SequenceRRSRRGRGGGRRGGSGGRGGRGGGGRSGAGSSIAGVGSRGGGGGRHYA
Length48
NameCathelicidin-AL (Gly-rich; Frogs, amphibians, animals)
SourceAmolops loloensis
ActivityAntimicrobial, Antibacterial, Anti-Gram+, Anti-Gram-, Antifungal
PathogenGram-positive bacteria: Staphylococcus aureus ATCC25923 (MIC=6.25 µg/ml), Staphylococcus aureus ATCC43300 (MIC=6.25 µg/ml), Bacillus subtilis (MIC=100 µg/ml);##Gram-negative bacteria: Escherichia coli ML-35P (MIC=25 µg/ml), Psecdomonas aeruginosa PA01 (MIC=12.5 µg/ml), Psecdomonas aeruginosa ATCC27853 (MIC=6.25 µg/ml).##Yeast: Candida albicans ATCC2002 (MIC=50 µg/ml).
Hemolytic ActivityNo hemolysis information or data found in the reference(s) presented in this entry
Cytotoxicity[Ref.22009138]No cytotoxic against HUVEC or RMMCs at the concentration of 0.4 mg/ml.
N-terminal ModificationFree
C-terminal ModificationFree
Linear/Cyclic/BranchedLinear
Uniprot
PDB
3D View
PDB DownloadDownload PDB Predicted by Alphafold2
PubMed ID22009138

Physicochemical Properties

Residues48
SequenceRRSRRGRGGGRRGGSGGRGGRGGGGRSGAGSSIAGVGSRGGGGGRHYA
Molecular Weight4452.722
Grand Average of Hydropathy-1.217
Isoelectric Point12
Charge at pH 7.411.591
Secondary StructureHelix: 0.062, Turn: 0.604, Sheet: 0.062
Instability Index110.737
Aromaticity0.021

Similar Structure Search

Candidates based on structure

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