Basic Information

IDDRAMP01353
SequenceRVCYAIPLPIC
Length11
NameTigerinin-4 (Frogs, amphibians, animals)
SourceRana tigerina (Indian bull frog)
ActivityAntimicrobial, Antibacterial, Anti-Gram+, Anti-Gram-, Antifungal
PathogenGram-positive bacterium: Staphylococcus aureus ATCC 8530 (MIC=50 µg/ml);##Gram-negative bacteria: Escherichia coli (MIC=60 µg/ml), Pseudomonas putida NCIM 2102 (MIC=60 µg/ml).##Fungi: Saccharomyces cerevisiae ATCC 8530 (MIC=100 µg/ml).
Hemolytic Activity[Ref.11031261] It exhibits no hemolytic activity up to a concentration of 200 μg/ml against rat erythrocytes.
CytotoxicityNo cytotoxicity information found
N-terminal ModificationFree
C-terminal ModificationAmidation;Cyclization (Cys3 and Cys11)
Linear/Cyclic/BranchedCyclic
Uniprot P82654
PDB
3D View
PDB DownloadDownload PDB Predicted by Alphafold2
PubMed ID11031261

Physicochemical Properties

Residues11
SequenceRVCYAIPLPIC
Molecular Weight1247.572
Grand Average of Hydropathy1.345
Isoelectric Point8.058
Charge at pH 7.40.506
Secondary StructureHelix: 0.455, Turn: 0.182, Sheet: 0.182
Instability Index45.509
Aromaticity0.091

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