Basic Information

IDDRAMP01354
SequenceLVRGCWTKSYPPKPCFVR
Length18
NamePeptide leucine arginine (pLR; Frogs, amphibians, animals)
SourceRana pipiens (Northern leopard frog)
ActivityAntimicrobial, Antibacterial, Anti-Gram+, Antifungal
Pathogen[Ref.11099505]Gram-positive bacteria: Bacillus megaterium Bm11 (MIC=20 µM), Staphylococcus lentus (MIC=50 µM), Micrococcus luteus (MIC=10 µM);##Fungi: Candida tropicalis (MIC=11 µM), Candida guillermondii (MIC=6.6 µM), Phytophthora nicotianae spores (MIC=75 µM).
Hemolytic Activity[Ref:11099505] It has 2.5% hemolytic activity at 100 μM against human red blood
CytotoxicityNo cytotoxicity information found
N-terminal ModificationFree
C-terminal ModificationFree
Linear/Cyclic/BranchedCyclic
Uniprot Q90WP7, P82110
PDB
3D View
PDB DownloadDownload PDB Predicted by Alphafold2
PubMed ID11099505

Physicochemical Properties

Residues18
SequenceLVRGCWTKSYPPKPCFVR
Molecular Weight2137.572
Grand Average of Hydropathy-0.317
Isoelectric Point9.847
Charge at pH 7.43.501
Secondary StructureHelix: 0.333, Turn: 0.278, Sheet: 0.056
Instability Index18.711
Aromaticity0.167

Similar Structure Search

Candidates based on structure

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