Basic Information

IDDRAMP02402
SequenceFLPKMSTKLRVPYRRGTKDYH
Length21
NameAntimicrobial peptide scolopin-1
SourceScolopendra mutilans (Chinese red-headed centipede) (Scolopendrasubspinipes mutilans)
ActivityAntimicrobial, Antibacterial, Anti-Gram+, Anti-Gram-, Antifungal
Pathogen[Ref.19716842]Gram-negative bacteria: Escherichia coli standard strain (MIC=12.5 µg/ml), E. coli drug-resistant strain (MIC=15 µg/ml);##Gram-positive bacteria: Staphylococcus aureus standard strain (MIC=1.2 µg/ml), S. aureus drug-resistant strain (MIC=5.0 µg/ml), Bacillus dysenteriae standard and drug-resistant strains (MIC=7.5 µg/ml);##Yeast: Candida albicans (MIC=15 µg/ml).
Hemolytic Activity[Ref.19716842]25 ± 2% hemolytic activity at 50 μg/ml against human red blood cells
CytotoxicityNot included yet
N-terminal ModificationNot included yet
C-terminal ModificationNot included yet
Linear/Cyclic/BranchedNot included yet
Uniprot P0CH48
PDB
3D View
PDB DownloadDownload PDB Predicted by Alphafold2
PubMed ID19716842

Physicochemical Properties

Residues21
SequenceFLPKMSTKLRVPYRRGTKDYH
Molecular Weight2594.045
Grand Average of Hydropathy-1.133
Isoelectric Point10.549
Charge at pH 7.44.582
Secondary StructureHelix: 0.286, Turn: 0.190, Sheet: 0.143
Instability Index86.457
Aromaticity0.143

Similar Structure Search

Candidates based on structure

Address: No.2699 Qianjin Street, Changchun City, China. Zip Code: 130012. 苏ICP备2021057230号-1.