Basic Information

IDDRAMP02432
SequencePDPGQPWQVKAGRPPCYSIPCRKHDECRVGSCSRCNNGLWGDRTCR
Length46
NameAntimicrobial peptide ISAMP (Ticks, Arthropods, animals)
SourceIxodes scapularis (Black-legged tick) (Deer tick)
ActivityAntimicrobial, Antibacterial, Anti-Gram+, Anti-Gram-
Pathogen[Ref.19852941]Gram-positive bacteria: Bacillus cereus (MIC=5.8 µg/ml), Bacillus subtilis (MIC=12.3 µg/ml), Staphylococcus aureus (MIC=10.4 µg/ml);##Gram-negative bacteria: Escherichia coli Edl 933 (MIC=3.2 µg/ml), E. coli MG/655 (MIC=4.2 µg/ml).
Hemolytic Activity[Ref.19852941]Insignificant hemolytic activity even up to 150 μg/ml against rabbit red blood cells
CytotoxicityNot included yet
N-terminal ModificationNot included yet
C-terminal ModificationNot included yet
Linear/Cyclic/BranchedNot included yet
Uniprot Q8MVA6
PDB
3D View
PDB DownloadDownload PDB Predicted by Alphafold2
PubMed ID12177149, 19852941

Physicochemical Properties

Residues46
SequencePDPGQPWQVKAGRPPCYSIPCRKHDECRVGSCSRCNNGLWGDRTCR
Molecular Weight5187.842
Grand Average of Hydropathy-1.093
Isoelectric Point8.979
Charge at pH 7.43.786
Secondary StructureHelix: 0.152, Turn: 0.348, Sheet: 0.065
Instability Index30.876
Aromaticity0.065

Similar Structure Search

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