Basic Information

IDDRAMP02643
SequenceRCLCRRGVCRCLCRRGVC
Length18
NameRhesus theta-defensin 2 (RTD-2; primates, mammals, animals)
SourceMacaca mulatta (Rhesus macaque)
ActivityAntimicrobial, Antibacterial, Antifungal, Anti-Gram+, Anti-Gram-
PathogenGram-positive bacteria: Staphylococcus aureus 502a, Listeria monocytogenes; ##Gram-negative bacteria: Salmonella typhimurium, Escherichia coli ML35.##Fungi: Candida albicans 16820, Cryptococcus neoformans 271A (the activity of RTD-2 against Escherichia coli ML35 was 2-3-fold less than those of RTD-1 and RTD-3).
Hemolytic ActivityNo hemolysis information or data found in the reference(s) presented in this entry
CytotoxicityNot included yet
N-terminal ModificationNot included yet
C-terminal ModificationNot included yet
Linear/Cyclic/BranchedNot included yet
Uniprot P82271
PDB
3D View
PDB DownloadDownload PDB Predicted by Alphafold2
PubMed ID10521339, 1152799, 11675394

Physicochemical Properties

Residues18
SequenceRCLCRRGVCRCLCRRGVC
Molecular Weight2112.667
Grand Average of Hydropathy0.178
Isoelectric Point9.687
Charge at pH 7.45.41
Secondary StructureHelix: 0.222, Turn: 0.111, Sheet: 0.111
Instability Index85.056
Aromaticity0

Similar Structure Search

Candidates based on structure

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