Basic Information

IDDRAMP02875
SequenceLPVNSPMNKGDTEVMKCIVEVISDTLSKPSPMPVSKECFETLRGDERILSILRHQNLLKELQDLALQGAKERTHQQ
Length76
NameVasostatin-1 (VS-1; N-terminal fragment of Chromogranin-A; mammals, animals)
SourceBos taurus (Bovine)
ActivityAntimicrobial, Antibacterial, Anti-Gram+, Antifungal
PathogenGram-positive bacteria: Micrococcus luteus (MIC=2 µM), Bacillus megaterium (MIC=0.2 µM).##Fungi: Neurospora crassa (MIC=3 µM), Aspergillus fumigatus (MIC=5 µM), Alternaria brassicicola (MIC=3 µM), Nectria haematococca (MIC=1 µM), Fusarium culmorum (MIC=1 µM), F. oxyporum (MIC=10 µM), Saccharomyces cerevisiae (MIC=10 µM), Candida albicans (MIC=10 µM).
Hemolytic ActivityNo hemolysis information or data found in the reference(s) presented in this entry
CytotoxicityNot included yet
N-terminal ModificationNot included yet
C-terminal ModificationNot included yet
Linear/Cyclic/BranchedNot included yet
Uniprot P05059, P79392, Q2KJ52
PDB
3D View
PDB DownloadDownload PDB Predicted by Alphafold2
PubMed ID10753865

Physicochemical Properties

Residues76
SequenceLPVNSPMNKGDTEVMKCIVEVISDTLSKPSPMPVSKECFETLRGDERILSILRHQNLLKELQDLALQGAKERTHQQ
Molecular Weight8585.846
Grand Average of Hydropathy-0.487
Isoelectric Point6.108
Charge at pH 7.4-1.424
Secondary StructureHelix: 0.263, Turn: 0.224, Sheet: 0.289
Instability Index62.583
Aromaticity0.013

Similar Structure Search

Candidates based on structure

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