Basic Information

IDDRAMP03227
SequenceGLFGKLIKKFGRKAISYAVKKARGKH
Length26
NameM-zodatoxin-Lt2a (M-ZDTX-Lt2a; Latarcin-2a, Ltc-2a, Ltc2a; spiders, Arthropods, animals)
SourceLachesana tarabaevi (Spider)
ActivityAntimicrobial, Antibacterial, Anti-Gram+, Anti-Gram-, Antifungal
Pathogen[Ref.16735513]Gram-positive bacteria: Arthrobacter globiformis VKM Ac-1112 (MIC=0.7 µM), Bacillus subtilis VKM B-501 (MIC=0.4 µM);##Gram-negative bacteria: Escherichia coli DH5-alpha (MIC=1.0 µM), Escherichia coli MH1 (MIC=0.7 µM), Pseudomonas aeruginosa PAO1 (MIC=6.7 µM);##Fungi: Pichia pastoris GS115 (MIC=6.7 µM), Saccharomyces cerevisiae Y190 (MIC=54 µM).
Hemolytic Activity[Ref.16735513]20% hemolytic activity at 6 μM against rabbit erythrocytes
CytotoxicityNot included yet
N-terminal ModificationNot included yet
C-terminal ModificationNot included yet
Linear/Cyclic/BranchedNot included yet
Uniprot Q1ELU1
PDB 2G9P
3D View
PDB DownloadDownload PDB Predicted by Alphafold2
PubMed ID16735513, 16939228

Physicochemical Properties

Residues26
SequenceGLFGKLIKKFGRKAISYAVKKARGKH
Molecular Weight2902.531
Grand Average of Hydropathy-0.438
Isoelectric Point11.334
Charge at pH 7.48.574
Secondary StructureHelix: 0.308, Turn: 0.192, Sheet: 0.192
Instability Index1.288
Aromaticity0.115

Similar Structure Search

Candidates based on structure

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