Basic Information

IDDRAMP03542
SequenceHKTDSFVGLM
Length10
NameNeurokinin A (NKA; chicken, animals)
SourceGallus gallus (Chicken)
ActivityAntimicrobial, Antibacterial, Neuropeptide, Anti-Gram+, Anti-Gram-
Pathogen[Ref.18603306] Gram-negative bacteria: Escherichia coli ATCC 25922 (MIC>500 μg/ml), Pseudomonas aeruginosa ATCC 27853 (MIC>500 μg/ml) ;## Gram-positive bacteria: Streptococcus mutans NCTC 10449 (MIC> 500 μg/ml), Lactobacillus acidophilus NCTC 1723 (MIC>500 μg/ml), Enterococcus faecalis NCTC 12697 (MIC>500 μg/ml), Staphylococcus aureus ATCC 25923 (MIC>500 μg/ml);## Yeast: Candida albicans NCTC 3179 (MIC>500 μg/ml).
Hemolytic ActivityNo hemolysis information or data found in the reference(s) presented in this entry
Cytotoxicity[Ref.18603306]No cytotoxicity information found
N-terminal ModificationFree
C-terminal ModificationAmidation
Linear/Cyclic/BranchedLinear
Uniprot P19851
PDB 1N6T
3D View
PDB DownloadDownload PDB Predicted by Alphafold2
PubMed ID18603306

Physicochemical Properties

Residues10
SequenceHKTDSFVGLM
Molecular Weight1134.305
Grand Average of Hydropathy0.02
Isoelectric Point6.744
Charge at pH 7.4-0.408
Secondary StructureHelix: 0.300, Turn: 0.200, Sheet: 0.200
Instability Index43.45
Aromaticity0.1

Similar Structure Search

Candidates based on structure

Address: No.2699 Qianjin Street, Changchun City, China. Zip Code: 130012. 苏ICP备2021057230号-1.