Basic Information
| ID | DRAMP03575 |
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| Sequence | FKRIVQRIKDFLR |
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| Length | 13 |
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| Name | LL-37(17-29) (C-terminal fragment of LL-37, LL; Human, mammals, animals) |
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| Source | Homo sapiens |
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| Activity | Antimicrobial, Antibacterial, Anti-Gram+, Anti-Gram-, Anti-cancer |
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| Pathogen | [Ref.16637646] Gram-negative bacterium: Escherichia coli K12(MIC=40 μM);##Drug-resistant KBv cancer cells (LC50=60 μM), Drug-sensitive KB cancer cells (LC50=57 μM).##[Ref.28178190]Gram-positive bacteria: Staphylococcus aureus ATCC 29213 (MIC=16 μM), S. faecalis ATCC 29212 (MIC=32 μM), Bacillus subtilis CMCC 63501 (MIC=16 μM), Staphylococcus epidermidis ATCC 12228 (MIC=8 μM);##Gram-negative bacteria: Escherichia coli ATCC 25922 (MIC=16 μM), Escherichia coli UB 1005 (MIC=16 μM), Pseudomonas aeruginosa ATCC 27853 (MIC=8 μM), Pseudomonas aeruginosa PAO1 (MIC=16 μM), Salmonella typhimurium ATCC 14028 (MIC=32 μM), Salmonella typhimurium ATCC 7731 (MIC=16 μM). [Ref.23894079] Gram-positive bacteria : Staphylococcus aureus (ATCC 29213)(MIC=40 μM);##Gram-negative bacteria : Escherichia coli (ATCC 25922)(MIC=5 μM) |
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| Hemolytic Activity | [Ref.28161291] HC50>256 μM against human red blood cells. [Ref.23894079] MHC10=160 μM against human red blood cells |
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| Cytotoxicity | Not included yet |
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| N-terminal Modification | Not included yet |
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| C-terminal Modification | Not included yet |
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| Linear/Cyclic/Branched | Not included yet |
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| Uniprot |
P49913 |
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| PDB |
2FBS |
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| 3D View | |
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| PDB Download | Download PDB Predicted by Alphafold2 |
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| PubMed ID | 16637646, 28178190, 28161291, 23894079 |
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