Basic Information

IDDRAMP03588
SequenceLAHQKPFIRKSYKCLHKRCR
Length20
NameHuman MUC7 20-Mer (Human, mammals, animals)
SourceHomo sapiens (Human)
ActivityAntimicrobial, Antibacterial, Anti-Gram+, Anti-Gram-, Antifungal
PathogenGram-positive bacteria: Streptococcus mutans (EC50=1.39 µM), Streptococcus gordonii (EC50=2.43 µM);##Gram-negative bacteria: Escherichia coli (EC50=1.61 µM), Pseudomonas aeruginosa (EC50=4.41 µM), Porphyromonas gingivalis (EC50<1 µM).##Fungi: Candida albicans (DIS) (EC50=5.85 µM), C. albicans (azole resistant) (EC50=2.40 µM), Candida glabrata (EC50=5.02 µM), C. glabrata (fluconazole resistant) (EC50=12.3 µM), Candida krusei (EC50=5.16 µM), Cryptococcus neoformans (EC50=4.05 µM), Cryptococcus neoformans (amphotericin B resistant) (EC50=4.29 µM), Saccharomyces cerevisiae (EC50=5.23 µM).
Hemolytic ActivityNo hemolysis information or data found in the reference(s) presented in this entry
CytotoxicityNot included yet
N-terminal ModificationNot included yet
C-terminal ModificationNot included yet
Linear/Cyclic/BranchedNot included yet
Uniprot
PDB
3D View
PDB DownloadDownload PDB Predicted by Alphafold2
PubMed ID12543672

Physicochemical Properties

Residues20
SequenceLAHQKPFIRKSYKCLHKRCR
Molecular Weight2513.045
Grand Average of Hydropathy-1.05
Isoelectric Point10.573
Charge at pH 7.46.569
Secondary StructureHelix: 0.250, Turn: 0.100, Sheet: 0.150
Instability Index48.885
Aromaticity0.1

Similar Structure Search

Candidates based on structure

Address: No.2699 Qianjin Street, Changchun City, China. Zip Code: 130012. 苏ICP备2021057230号-1.