Basic Information

IDDRAMP03638
SequenceLCLDQKPEMEPFRKDAQQALEPSRQRRWLHRRCLSGRGFCRAICSIFEEPVRGNIDCYFGYNCCRRMFSHYRTS
Length74
NameVpBD (V.philippinarum beta defensin; big defensin)
SourceVenerupis philippinarum (The manila clam)
ActivityAntimicrobial, Antibacterial, Anti-Gram+, Anti-Gram-
PathogenGram-positive bacteria: Staphyloccocus aureus (MIC=1.64-3.28 µM), Micrococcus luteus (MIC>26.26 µM), Bacillus sp. (MIC=13.13-26.26 µM);##Gram-negative bacteria: Vibrio anguillarum (MIC=13.13-26.26 µM), Entherobacter cloacae (MIC>26.26 µM), Vibrio ichthyoenteri (MIC=3.28-6.56 µM), Pseudomonas putida (MIC=1.64-3.28 µM), Proteus mirabilis (MIC>26.26 µM), Enterobacter sp. (MIC=13.13-26.26 µM)
Hemolytic ActivityNo hemolysis information or data found in the reference(s) presented in this entry
CytotoxicityNo cytotoxicity information found
N-terminal ModificationFree
C-terminal ModificationFree
Linear/Cyclic/BranchedCyclic
Uniprot
PDB
3D View
PDB DownloadDownload PDB Predicted by Alphafold2
PubMed ID20975988

Physicochemical Properties

Residues74
SequenceLCLDQKPEMEPFRKDAQQALEPSRQRRWLHRRCLSGRGFCRAICSIFEEPVRGNIDCYFGYNCCRRMFSHYRTS
Molecular Weight8921.194
Grand Average of Hydropathy-0.774
Isoelectric Point9.205
Charge at pH 7.45.453
Secondary StructureHelix: 0.243, Turn: 0.203, Sheet: 0.203
Instability Index81.472
Aromaticity0.122

Similar Structure Search

Candidates based on structure

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