Basic Information

IDDRAMP03743
SequenceRSVCRQIKICRRRGGCYYKCTNRPY
Length25
NameAndroctonin (Arthropods, animals)
SourceAndroctonus australis (Sahara scorpion)
ActivityAntimicrobial, Antibacterial, Anti-Gram+, Anti-Gram-, Antifungal
Pathogen[Ref.10942757] Gram-positive bacteria: Micrococcus luteus (MIC=0.6-1.5 μM), Aerococcus viridans (MIC=0.3-0.6 μM), Staphylococcus aureus (MIC=15-30 μM);##Gram-negative bacteria: Escherichia coli D31 (MIC=3-6 μM), Escherichia coli D22 (MIC=6-15 μM), Escherichia coli 1106 (MIC=6-15 μM), Salmonella typhimurium (MIC=3-6 μM).##Fungi: Alternaria brassicola (MIC=3-6 μM), Fusarium culmorum (MIC=3-6 μM), Fusarium oxysporum (MIC=6-12 μM), Neurospora crassa (MIC=6-12 μM), Nectria haematococca (MIC=6-12 μM), Trichoderma viridae (MIC=6-12 μM);##Yeast: Candida albicans (MIC=1.6-3.15 μM).##[Ref.8939880] Gram-positive bacteria: Bacillus subtilis (MIC=1.5-3.0 μM);##Gram-negative bacteria: Escherichia coli D22 (MIC>30 μM), Pseudomonas syringae (MIC=1.5-3.0 μM), Pseudomonas syringae pv.syringae (MIC=15-22 μM), Pseudomonas syringae phaseoli (MIC=1.5-3.0 μM), Pseudomonas syringae pv.pisi (MIC=6-15 μM), Pseudomonas syringae pv. maculicola (MIC=3-6 μM), Phoma valerianella (MIC=15-22 μM), Xanthomonas compestris pv.compestris (MIC=3-6 μM), Xanthomonas vesicatoria 687.3 (MIC=1.5-3.0 μM), Xanthomonas vesicatoria B229RI (MIC=1.5-3.0 μM);##Fungi: Alternaria dauci (MIC=8-16 μM), Stemphylium (MIC=4-8 μM), Fusarium oxysporum M. (MIC=2-4 μM), Fusarium oxysporum L. (MIC=2-4 μM), Botrytis cinerea (MIC=6-12 μM), B. petunia (MIC=4-8 μM), Verticilium toreilis (MIC=2-4 μM), Aspergillus fumigatus (MIC=25-50 μM).
Hemolytic Activity[Ref.8939880] It exhibits no hemolytic activity on porcine or bovine erythrocytes at a concentration of up to 150 μM.
CytotoxicityNo cytotoxicity information found
N-terminal ModificationFree
C-terminal ModificationFree
Linear/Cyclic/BranchedCyclic
Uniprot P56684
PDB 1CZ6
3D View
PDB DownloadDownload PDB Predicted by Alphafold2
PubMed ID8939880, 10563585, 10942757

Physicochemical Properties

Residues25
SequenceRSVCRQIKICRRRGGCYYKCTNRPY
Molecular Weight3080.642
Grand Average of Hydropathy-1.056
Isoelectric Point10.223
Charge at pH 7.47.447
Secondary StructureHelix: 0.240, Turn: 0.200, Sheet: 0.000
Instability Index95.12
Aromaticity0.12

Similar Structure Search

Candidates based on structure

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