| ID | DRAMP03977 |
|---|---|
| Sequence | WKKIPKFLHLLKKF |
| Length | 14 |
| Name | N-5L (analog of P18) |
| Source | Synthetic construct |
| Activity | Antimicrobial, Antibacterial, Anti-Gram+, Anti-Gram-, Antitumor |
| Pathogen | Gram-negative bacteria: Escherichia coli KCTC 1682 (MIC=6.25 µM), Pseudomonas aeruginosa KCTC 1637 (MIC=3.125 µM), Proteus vulgaris (MIC=12.5 µM).##Gram-positive bacteria: Bacillus subtilis KCTC 1918 (MIC=0.78 µM), Staphylococcus aureus KCTC 1621 (MIC=3.125 µM), Bacillus megaterium KCTC 1096 (MIC=1.56 µM).##Tumor cells: MDA-MB-361 (IC50=17.0 µM), Jurkat (IC50=14.0 µM), K-562 (IC50=10.0 µM), Normal cells NIH 3T3 (IC50=50.0 µM). |
| Hemolytic Activity | No hemolysis information or data found in the reference(s) presented in this entry |
| Cytotoxicity | Not included yet |
| N-terminal Modification | Not included yet |
| C-terminal Modification | Not included yet |
| Linear/Cyclic/Branched | Not included yet |
| Uniprot | |
| PDB | |
| 3D View | |
| PDB Download | Download PDB Predicted by Alphafold2 |
| PubMed ID | 12005420 |
Physicochemical Properties
| Residues | 14 |
|---|---|
| Sequence | WKKIPKFLHLLKKF |
| Molecular Weight | 1826.319 |
| Grand Average of Hydropathy | -0.264 |
| Isoelectric Point | 10.602 |
| Charge at pH 7.4 | 4.582 |
| Secondary Structure | Helix: 0.500, Turn: 0.071, Sheet: 0.214 |
| Instability Index | -4.9 |
| Aromaticity | 0.214 |