Basic Information

IDDRAMP03978
SequenceKWKLFKKIPFLHLAKKF
Length17
NameC-1 (analog of P18)
SourceSynthetic construct
ActivityAntimicrobial, Antibacterial, Anti-Gram+, Anti-Gram-, Antitumor
PathogenGram-negative bacteria: Escherichia coli KCTC 1682 (MIC=6.25 µM), Pseudomonas aeruginosa KCTC 1637 (MIC=6.25 µM), Proteus vulgaris (MIC=1.56 µM).##Gram-positive bacteria: Bacillus subtilis KCTC 1918 (MIC=0.78 µM), Staphylococcus aureus KCTC 1621 (MIC=3.125 µM), Bacillus megaterium KCTC 1096 (MIC=1.56 µM).##Tumor cells: MDA-MB-361 (IC50=26.0 µM), Jurkat (IC50=32.0 µM), K-562 (IC50=31.0 µM), Normal cells NIH 3T3 (IC50=100.0 µM).
Hemolytic ActivityNo hemolysis information or data found in the reference(s) presented in this entry
CytotoxicityNot included yet
N-terminal ModificationNot included yet
C-terminal ModificationNot included yet
Linear/Cyclic/BranchedNot included yet
Uniprot
PDB
3D View
PDB DownloadDownload PDB Predicted by Alphafold2
PubMed ID12005420

Physicochemical Properties

Residues17
SequenceKWKLFKKIPFLHLAKKF
Molecular Weight2172.743
Grand Average of Hydropathy-0.176
Isoelectric Point10.699
Charge at pH 7.45.579
Secondary StructureHelix: 0.471, Turn: 0.059, Sheet: 0.235
Instability Index0.218
Aromaticity0.235

Similar Structure Search

Candidates based on structure

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