Basic Information

IDDRAMP04079
SequenceAKKVFKRLEKSFSKIQNDK
Length19
NameAnal 4 (antimicrobial peptide HP (2-20)analogue)
SourceSynthetic construct (amino acid substitution)
ActivityAntimicrobial, Antibacterial, Anti-Gram+, Anti-Gram-, Antifungal
PathogenGram-positive bacteria: Bacillus subtilis (MIC=6.25 µg/ml), Staphylococcus epidermidis (MIC>12.5 µg/ml), Staphylococcus aureus (MIC>12.5 µg/ml), Listeria monocytogenes (MIC>12.5 µg/ml);##Gram-negative bacteria: Escherichia coli (MIC=12.5 µg/ml), Salmonella typhimurium (MIC=12.5 µg/ml), Proteus vulgaris (MIC>12.5 µg/ml), Pseudomonas aeruginosa (MIC=12.5 µg/ml), Escherichia coli O157 (MIC>12.5 µg/ml).##Fungi: Trichosporon beigelii (MIC=12.5 µg/ml), Candida albicans (MIC>25 µg/ml), Saccharomyces cerevisiae (MIC>25 µg/ml), Aspergillus flavus (MIC>50 µg/ml), Aspergillus fumigatus (MIC>50 µg/ml), Botrytis cinerea (MIC>50 µg/ml), Fusarium moniliforme (MIC>50 µg/ml).
Hemolytic ActivityNo hemolysis information or data found in the reference(s) presented in this entry
CytotoxicityNot included yet
N-terminal ModificationNot included yet
C-terminal ModificationNot included yet
Linear/Cyclic/BranchedNot included yet
Uniprot P56029
PDB 1P5K
3D View
PDB DownloadDownload PDB Predicted by Alphafold2
PubMed ID16255716, PubMed ID is not available

Physicochemical Properties

Residues19
SequenceAKKVFKRLEKSFSKIQNDK
Molecular Weight2294.694
Grand Average of Hydropathy-1.242
Isoelectric Point10.295
Charge at pH 7.44.594
Secondary StructureHelix: 0.263, Turn: 0.158, Sheet: 0.158
Instability Index5.316
Aromaticity0.105

Similar Structure Search

Candidates based on structure

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