| ID | DRAMP04340 |
|---|---|
| Sequence | IGKKFKRIVKRIKKFLRKL |
| Length | 19 |
| Name | a4 (IG-19 analogs) |
| Source | Synthetic construct |
| Activity | Antimicrobial, Antibacterial, Anti-Gram+, Anti-Gram- |
| Pathogen | [Ref.22521196] Gram-positive bacteria : Bacillus subtilis (KCTC 3068)(MIC=2 μM), Staphylococcus epidermidis (KCTC 1917)(MIC=4 μM), Staphylococcus aureus (KCTC 1621)(MIC=4 μM);##Gram-negative bacteria : Escherichia coli (KCTC 1682)(MIC=8 μM), Pseudomonas aeruginosa (KCTC 1637)(MIC=8 μM), Salmonella typhimurium (KCTC 1926)(MIC=2 μM) |
| Hemolytic Activity | [Ref.22521196] MHC10=33.2 μM against human red blood cells |
| Cytotoxicity | Not included yet |
| N-terminal Modification | Not included yet |
| C-terminal Modification | Not included yet |
| Linear/Cyclic/Branched | Not included yet |
| Uniprot | |
| PDB | |
| 3D View | |
| PDB Download | Download PDB Predicted by Alphafold2 |
| PubMed ID | 22521196 |
Physicochemical Properties
| Residues | 19 |
|---|---|
| Sequence | IGKKFKRIVKRIKKFLRKL |
| Molecular Weight | 2400.096 |
| Grand Average of Hydropathy | -0.542 |
| Isoelectric Point | 12 |
| Charge at pH 7.4 | 9.54 |
| Secondary Structure | Helix: 0.421, Turn: 0.053, Sheet: 0.105 |
| Instability Index | 26.626 |
| Aromaticity | 0.105 |