Basic Information

IDDRAMP18365
SequenceINTWNTTATSTSIIISETFGNKGKVCTYTVECVNNCRG
Length38
NameThusin (ThsA1, ThsA2; a two-chain lantibiotic, type 2, class 1 bacteriocins)
SourceBacillus thuringiensis strain BGSC 4BT1, serovar rongseni
ActivityAntimicrobial, Antibacterial
PathogenActive against S. pneumoniae ATCC 49619, B. cereus ATCC 14579, B. thuringiensis BMB171, B. pumilus SCG I , B. subtilis Bsn5, L. monocytogenes LM201 (MIC 6.25 uM), L. monocytogenes LM605, S. aureus ATCC 43300, S. sciuri Bom1, B. amyloliquefaciens X1 (MIC 12.5 uM), S. aureus CMCC 26003, MRSA (MIC 25 uM), and E. faecalis ATCC 29212 (MIC 50 uM).
Hemolytic ActivityNo hemolysis information or data found in the reference(s) presented in this entry
CytotoxicityNot included yet
N-terminal ModificationNot included yet
C-terminal ModificationNot included yet
Linear/Cyclic/BranchedNot included yet
Uniprot
PDB
3D View
PDB DownloadDownload PDB Predicted by Alphafold2
PubMed ID27486447

Physicochemical Properties

Residues38
SequenceINTWNTTATSTSIIISETFGNKGKVCTYTVECVNNCRG
Molecular Weight4127.591
Grand Average of Hydropathy-0.145
Isoelectric Point7.941
Charge at pH 7.40.479
Secondary StructureHelix: 0.263, Turn: 0.289, Sheet: 0.079
Instability Index23.103
Aromaticity0.079

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