Basic Information

IDDRAMP18648
SequenceFVPWFSKFLPRIL
Length13
Name[Pro3,DLeu9]TL(3) (Temporin L peptide derivative)
SourceSynthetic construct
ActivityAntimicrobial, Antibacterial, Anti-Gram+, Anti-Gram-, Antifungal
Pathogen[Ref.28863356] Gram-positive bacterium: Bacillus megaterium Bm11 (MIC=3.125μM), Staphylococcus epidermidis ATCC 12228 (MIC=25μM);##Gram-negative bacteria: Acinetobacter baumannii ATCC 19606 (MIC=50μM), Escherichia coli D21 (MIC=50μM), Pseudomonas syringae pv tabaci 1918 (MIC=50μM);##Yeasts: Candida albicans ATCC 10231 (MIC=3.125μM), Candida crusei ATCC 6258 (MIC=3.125μM).
Hemolytic ActivityNo hemolysis information or data found in the reference(s) presented in this entry
CytotoxicityNot included yet
N-terminal ModificationNot included yet
C-terminal ModificationNot included yet
Linear/Cyclic/BranchedNot included yet
Uniprot
PDB
3D View
PDB DownloadDownload PDB Predicted by Alphafold2
PubMed ID28863356

Physicochemical Properties

Residues13
SequenceFVPWFSKFLPRIL
Molecular Weight1650.016
Grand Average of Hydropathy0.877
Isoelectric Point11.001
Charge at pH 7.41.555
Secondary StructureHelix: 0.615, Turn: 0.231, Sheet: 0.154
Instability Index45.662
Aromaticity0.308

Similar Structure Search

Candidates based on structure

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