Basic Information

IDDRAMP18707
SequenceRRIRPRPPRLPRPRPRPLPFPRPGPRPIPRPLPFPRPGPRPIPRPLPFPRPGPRPIPRPL
Length60
NameBACTENECIN 7 (bac 7, Pro-rich; bovine cathelicidin, cattle, ruminant, mammals, animals)
SourceBos taurus (Bovine neutrophils)
ActivityAntimicrobial, Antibacterial, Anti-Gram-, Anti-Gram+
Pathogen[Ref.2777377] Gram-negative bacteria: Escherichia coli ATCC 25922 (MIC=12 µg/ml in Murller-Hinton, MIC=50 µg/ml in Iso-Sensitest), Salmonella typhimurium LT2 (MIC=12 µg/ml in Murller-Hinton, MIC=200 µg/ml in Iso-Sensitest), Salmonella typhimurium ATCC 14028 (MIC=25 µg/ml in Murller-Hinton, MIC=100 µg/ml in Iso-Sensitest), Klebsiella pneumoniae ATCC 13883 (MIC=12 µg/ml in Murller-Hinton, MIC=200 µg/ml in Iso-Sensitest), Enterobacter cloacae ATCC 13047 (MIC=25 µg/ml in Murller-Hinton, MIC=200 µg/ml in Iso-Sensitest), Pseudomonas aeruginosa ATCC 7700 (MIC=50 µg/ml in Murller-Hinton);##Gram-positive bacterium: Staphylococcus epidermidis ATCC 12228 (MIC=200 µg/ml in Murller-Hinton, MIC=200 µg/ml in Iso-Sensitest).
Hemolytic ActivityNo hemolysis information or data found in the reference(s) presented in this entry
CytotoxicityNot included yet
N-terminal ModificationNot included yet
C-terminal ModificationNot included yet
Linear/Cyclic/BranchedNot included yet
Uniprot P19661
PDB 4JWC resolved by NMR
3D View
PDB DownloadDownload PDB Predicted by Alphafold2
PubMed ID2777377

Physicochemical Properties

Residues60
SequenceRRIRPRPPRLPRPRPRPLPFPRPGPRPIPRPLPFPRPGPRPIPRPLPFPRPGPRPIPRPL
Molecular Weight7023.492
Grand Average of Hydropathy-1.285
Isoelectric Point12
Charge at pH 7.416.557
Secondary StructureHelix: 0.200, Turn: 0.517, Sheet: 0.083
Instability Index80.597
Aromaticity0.05

Similar Structure Search

Candidates based on structure

Address: No.2699 Qianjin Street, Changchun City, China. Zip Code: 130012. 苏ICP备2021057230号-1.