Basic Information

IDDRAMP20860
SequenceKFRTRRSKSSSNGGRKGSKGGSKGRPGSGSSIAGA
Length35
NameTT(1-35)
SourceSynthetic construct
ActivityAntimicrobial, Antibacterial, Anti-Gram+, Anti-Gram-
Pathogen[Ref.27818338]Gram-negative bacteria:Escherichia coli (ATCC 25922)(MIC=4μM);A. salmonicida (ATCC 33658)(MIC=2μM);Y. ruckeri (NCIMB 1315)(MIC=8μM);V. anguillarum (ATCC 43305 With addition of 2% NaCl)(MIC>32μM);A. hydrophila (ATCC 7966)(MIC>32μM);##Gram-positive bacteria:Staphylococcus aureus (ATCC 25923)(MIC=16-8μM);L. garvieae (ATCC 49156)(MIC=1μM)
Hemolytic Activity[Ref.27818338] No hemolytic activity to human;No hemolytic activity to trout
Cytotoxicity[Ref.27818338] The cell viability of RTG-2 cells is 106%, 117%, 126% and 121.5% at peptide concentrations of 0.25, 1, 4, and 8 μM.
N-terminal ModificationFree
C-terminal ModificationFree
Linear/Cyclic/BranchedLinear
Uniprot
PDB
3D View
PDB DownloadDownload PDB Predicted by Alphafold2
PubMed ID27818338

Physicochemical Properties

Residues35
SequenceKFRTRRSKSSSNGGRKGSKGGSKGRPGSGSSIAGA
Molecular Weight3451.772
Grand Average of Hydropathy-1.363
Isoelectric Point12
Charge at pH 7.49.545
Secondary StructureHelix: 0.057, Turn: 0.571, Sheet: 0.057
Instability Index53.7
Aromaticity0.029

Similar Structure Search

Candidates based on structure

Address: No.2699 Qianjin Street, Changchun City, China. Zip Code: 130012. 苏ICP备2021057230号-1.