Basic Information
| ID | DRAMP20927 |
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| Sequence | RRPWRWPWWPWRR |
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| Length | 13 |
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| Name | IN2(designed based on indolicidin and ranalexin) |
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| Source | Synthetic construct |
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| Activity | Antimicrobial, Antibacterial, Anti-Gram+, Anti-Gram- |
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| Pathogen | [Ref.26046345] Gram-negative bacteria: Escherichia coli ATCC 25922(MIC=31.25μg/ml), Pseudomonas aeruginosa ATCC 15442(MIC=31.25μg/ml), Acinetobacter baumanii ATCC 15308(MIC>250μg/ml), citrobacter spp(MIC>250μg/ml), Klebsiella pneumoniae(MIC>250μg/ml) ;## Gram-positive bacteria: Streptococcus pneumoniae(30 clinical isolates)(MIC=31.25–62.5μg/ml), Staphylococcus aureus ATCC 25923(MIC=31.25μg/ml), Methicillin resistant Staphylococcus aureus (MRSA)(MIC=31.25μg/ml), Enterococcus cloacae(MIC>250μg/ml), |
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| Hemolytic Activity | [Ref.26046345] IN2 showed 15.39% hemolytic activity at concentration of 250μg/ml against human RBCs. |
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| Cytotoxicity | [Ref.26046345] The cell viability of NL-20 cell line is not affected (<10%) below 62.5 μg/ml. The cell viability of NL-20 is 40% and 19% at peptide concentrations of 125 and 250 μg/ml.## The cell viability of WRL-68 cell line is not affected (<10%) bel |
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| N-terminal Modification | Free |
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| C-terminal Modification | Amidation |
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| Linear/Cyclic/Branched | Linear |
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| Uniprot |
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| PDB |
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| 3D View | |
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| PDB Download | Download PDB Predicted by Alphafold2 |
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| PubMed ID | 26046345 |
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