Basic Information

IDDRAMP21038
SequenceWGRRGWGPGRRYVRN
Length15
Nameanalog 1 (Derived from Ib-AMP1)
SourceSynthetic construct
ActivityAntimicrobial, Antibacterial, Anti-Gram+, Anti-Gram-
Pathogen[Ref.19778562] Gram-positive bacteria : Bacillus subtilis(KCTC 3068)(MIC=8 μM), Staphylococcus epidermidis(KCTC 1917)(MIC=8 μM), Staphylococcus aureus(KCTC 1621)(MIC=4 μM), Staphylococcus aureus (MRSA)(CCARM 3543)(MIC=2 μM);##Gram-negative bacteria : Escherichia coli(KCTC 1682)(MIC=16 μM), Pseudomonas aeruginosa(KCTC 1637)(MIC=16 μM), Salmonella typhimurium(KCTC 1926)(MIC=4 μM), Pseudomonas aeruginosa (MDRPA)(CCARM 2095)(MIC=16 μM)
Hemolytic Activity[Ref.19778562] MHC>400 μM against human red blood cells
Cytotoxicity[Ref.19778562] No cytotoxicity information found.
N-terminal ModificationFree
C-terminal ModificationAmidation
Linear/Cyclic/BranchedLinear
Uniprot
PDB
3D View
PDB DownloadDownload PDB Predicted by Alphafold2
PubMed ID19778562

Physicochemical Properties

Residues15
SequenceWGRRGWGPGRRYVRN
Molecular Weight1873.091
Grand Average of Hydropathy-1.873
Isoelectric Point12
Charge at pH 7.44.555
Secondary StructureHelix: 0.267, Turn: 0.400, Sheet: 0.000
Instability Index77.647
Aromaticity0.2

Similar Structure Search

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