Basic Information

IDDRAMP21042
SequenceILPWKWPWWKWRR
Length13
NameA2 (Derived from Indolicidin (IN))
SourceSynthetic construct
ActivityAntimicrobial, Antibacterial, Anti-Gram+, Anti-Gram-
Pathogen[Ref.19428758] Gram-positive bacteria : Bacillus subtilis(MIC=10 μg/ml), Staphylococcus epidermidis(MIC=10 μg/ml), Staphylococcus aureus(MIC=5 μg/ml);##Gram-negative bacteria : Escherichia coli(MIC=20 μg/ml), Pseudomonas aeruginosa(MIC=20 μg/ml), Salmonella typhimurium(MIC=10 μg/ml)
Hemolytic Activity[Ref.19428758] HC50=490 μg/ml against human red blood cells
Cytotoxicity[Ref.19428758] No cytotoxicity information found.
N-terminal ModificationFree
C-terminal ModificationAmidation
Linear/Cyclic/BranchedLinear
Uniprot
PDB
3D View
PDB DownloadDownload PDB Predicted by Alphafold2
PubMed ID19428758

Physicochemical Properties

Residues13
SequenceILPWKWPWWKWRR
Molecular Weight1938.326
Grand Average of Hydropathy-1.246
Isoelectric Point12
Charge at pH 7.43.552
Secondary StructureHelix: 0.538, Turn: 0.154, Sheet: 0.077
Instability Index78.492
Aromaticity0.385

Similar Structure Search

Candidates based on structure

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