Basic Information

IDDRAMP21045
SequenceILPWKWKWWKWRR
Length13
NameA5 (Derived from Indolicidin (IN))
SourceSynthetic construct
ActivityAntimicrobial, Antibacterial, Anti-Gram+, Anti-Gram-
Pathogen[Ref.19428758] Gram-positive bacteria : Bacillus subtilis(MIC=5 μg/ml), Staphylococcus epidermidis(MIC=10 μg/ml), Staphylococcus aureus(MIC=5 μg/ml);##Gram-negative bacteria : Escherichia coli(MIC=10 μg/ml), Pseudomonas aeruginosa(MIC=10 μg/ml), Salmonella typhimurium(MIC=10 μg/ml)
Hemolytic Activity[Ref.19428758] HC50>800 μg/ml against human red blood cells
Cytotoxicity[Ref.19428758] No cytotoxicity information found.
N-terminal ModificationFree
C-terminal ModificationAmidation
Linear/Cyclic/BranchedLinear
Uniprot
PDB
3D View
PDB DownloadDownload PDB Predicted by Alphafold2
PubMed ID19428758

Physicochemical Properties

Residues13
SequenceILPWKWKWWKWRR
Molecular Weight1969.384
Grand Average of Hydropathy-1.423
Isoelectric Point12
Charge at pH 7.44.55
Secondary StructureHelix: 0.538, Turn: 0.077, Sheet: 0.077
Instability Index80.708
Aromaticity0.385

Similar Structure Search

Candidates based on structure

Address: No.2699 Qianjin Street, Changchun City, China. Zip Code: 130012. 苏ICP备2021057230号-1.