Basic Information

IDDRAMP21100
SequenceWRWRCRRRFCRWRW
Length14
NameWR2 (Derived from PG-1)
SourceSynthetic construct
ActivityAntimicrobial, Antibacterial, Anti-Gram+, Anti-Gram-
Pathogen[Ref.24621994] Gram-positive bacteria : Staphylococcus aureus(MIC=4 μM), Staphylococcus epidermidis(MIC=2 μM), Streptococcus faecalis(MIC=2 μM), Bacillus subtilis(MIC=1 μM);##Gram-negative bacteria : Escherichia coli(MIC=4 μM), Salmonella pullorum(MIC=2 μM), Salmonella typhimurium(MIC=4 μM), Bacteriump yocyaneum(MIC=8 μM)
Hemolytic Activity[Ref.24621994] MHC10=64 μM against human red blood cells
Cytotoxicity[Ref.24621994] No cytotoxicity information found.
N-terminal ModificationFree
C-terminal ModificationAmidation
Linear/Cyclic/BranchedLinear
Uniprot
PDB
3D View
PDB DownloadDownload PDB Predicted by Alphafold2
PubMed ID24621994

Physicochemical Properties

Residues14
SequenceWRWRCRRRFCRWRW
Molecular Weight2209.614
Grand Average of Hydropathy-1.95
Isoelectric Point12
Charge at pH 7.46.508
Secondary StructureHelix: 0.357, Turn: 0.000, Sheet: 0.000
Instability Index213.857
Aromaticity0.357

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