Basic Information
| ID | DRAMP21187 |
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| Sequence | WLRAFRRLVRRLARLLRR |
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| Length | 18 |
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| Name | WRL4 (Derived from leucocin A) |
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| Source | Synthetic construct |
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| Activity | Antimicrobial, Antibacterial, Anti-Gram+, Anti-Gram-, Antifungal |
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| Pathogen | [Ref.28002968] Gram-positive bacteria : Staphylococcus aureus 29213(MIC=6.65 μM), Staphylococcus aureus 1.160(MIC=1.66 μM), Listeria monocytogenes 21662(MIC=3.32 μM), Listeria monocytogenes 21633(MIC=3.32 μM), Bacillus cereus 63301(MIC=53.18 μM), Micrococcus luteus 28001(MIC=13.29 μM), Bacillus pumilus 63202(MIC=26.59 μM), Pseudomonas fluorescens 21620(MIC=53.18 μM), MRSA 43300(MIC=3.32 μM);##Gram-negative bacteria : Escherichia coli O157 : H7 21530(MIC=3.32 μM), Escherichia coli 25922(MIC=13.29 μM), Escherichia coli 35150(MIC=26.59 μM), Salmonella paratyphi-A 20501(MIC=6.65 μM), Salmonella paratyphi paratyphi-B 21495(MIC=3.32 μM), Salmonella paratyphi paratyphi-C 21512(MIC=6.65 μM), Shigella flexneri 51571(MIC=1.66 μM), Salmonella choleraesuis 13312(MIC=13.29 μM), Salmonella typhimurium 51005(MIC>53.18 μM), Salmonella enteritidis 21527(MIC>53.28 μM), Vibrio parahemolyticus 21617(MIC=6.65 μM);##Fungi : Candida albicans 10231(MIC=26.59 μM) |
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| Hemolytic Activity | [Ref.28002968] MHC10=53.18 μM against human red blood cells |
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| Cytotoxicity | [Ref.28002968] The cell viability of RAW264.7 cells induced by WRL4 is 91.27%, 90.42%, 81.13%, 73.24%, 70.14%, 69.30%, 56.62%, 51.27% and 48.25% at peptide concentrations of 0.25, 0.5, 1, 2, 4, 8, 16, 32 and 64 μM. |
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| N-terminal Modification | Free |
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| C-terminal Modification | Amidation |
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| Linear/Cyclic/Branched | Linear |
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| Uniprot |
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| PDB |
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| 3D View | |
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| PDB Download | Download PDB Predicted by Alphafold2 |
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| PubMed ID | 28002968 |
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