Basic Information

IDDRAMP21259
SequenceMDSFQKIEKIGEGTYGVVYKAKDKVSGRLVALKKIRLENESEGVPSTA
Length48
NameScolopendin 1 (Centipedes, Arthropoda, Animals)
SourceSynthetic construct
ActivityAntimicrobial, Antibacterial, Anti-Gram+, Anti-Gram-, Antifungal
Pathogen[Ref.25209888] Gram-positive bacteria : Staphylococcus aureus ATCC 25923(MIC=5.0 ± 4.3 μM), Enterococcus faecium ATCC 19434(MIC=10.0 ± 8.7 μM);##Gram-negative bacteria : Escherichia coli O-157 ATCC 43895(MIC=5.0 ± 4.3 μM), Pseudomonas aeruginosa ATCC 27853(MIC= 5.0 ± 4.3 μM);##Fungi : Candida albicans ATCC 90028(MIC=10.0 ± 8.7 μM), Candida parapsilosis ATCC 22019(MIC= 10.0 ± 8.7 μM), Trichosporon beigelii KCTC 7707(MIC=20.0 ± 17.3 μM)
Hemolytic Activity[Ref.25209888] 0% hemolysis at 80 μM against human red blood cells
Cytotoxicity[Ref.25209888] No cytotoxicity information found
N-terminal ModificationFree
C-terminal ModificationAmidation
Linear/Cyclic/BranchedLinear
Uniprot
PDB
3D View
PDB DownloadDownload PDB Predicted by Alphafold2
PubMed ID25209888

Physicochemical Properties

Residues48
SequenceMDSFQKIEKIGEGTYGVVYKAKDKVSGRLVALKKIRLENESEGVPSTA
Molecular Weight5271.009
Grand Average of Hydropathy-0.471
Isoelectric Point9.1
Charge at pH 7.41.269
Secondary StructureHelix: 0.292, Turn: 0.229, Sheet: 0.250
Instability Index21.717
Aromaticity0.062

Similar Structure Search

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