Basic Information

IDDRAMP21371
SequenceFLGALWKVAKKVF
Length13
Name[Lys]7[Lys]11-VmCT1-NH2 (Derived from VmCT1)
Sourcesynthetic construct
ActivityAntimicrobial, Antibacterial, Anti-Gram+, Anti-Gram-, Antifungal
Pathogen[Ref.31181304] Gram-positive bacteria: Micrococcus luteus A270 (MIC=0.4 μmol/L), Staphylococcus aureus ATCC 29213 (MIC=0.8 μmol/L), Bacillus megaterium ATCC 10778 (MIC=0.4 μmol/L), Staphylococcus epidermidis ATCC 12228 (MIC=6.3 μmol/L);##Gram-negative bacteria: Escherichia coli SBS 363 (MIC=3.1 μmol/L)，Serratia marcescens ATCC 4112 (MIC=0.2 μmol/L), Enterobacter cloacae β-12 (MIC=3.1 μmol/L);##Fungi: Candida albicans MDM8 (MIC=1.6 μmol/L), Candida tropicalis IOC 4560 (MIC=0.4μmol/L)
Hemolytic Activity[Ref.31181304] 45% hemolysis at 12.5 μmol/L, 100% hemolysis at 50 μmol/L against human red blood cells
Cytotoxicity[Ref.31181304] ①The cell viability of MCF-7 cells induced by [Lys7][Lys11]-VmCT1-NH2 is 105%, 105%, 95%, 85%, 65%, 45%, 25% and 25% at peptide concentrations of 0.8, 1.6, 3.1, 12.5, 25, 50 and 100 μM. ②The cell viability of MCF-10A cells induced by [Lys7][Lys11]-VmCT1-NH2 is 120%, 120%, 85%, 90%, 120% and 120%at peptide concentrations of 0.8, 1.6, 3.1, 6.3, 12.5 and 25 μM.
N-terminal ModificationFree
C-terminal ModificationAmidation
Linear/Cyclic/BranchedLinear
Uniprot
PDB
3D View
PDB DownloadDownload PDB Predicted by Alphafold2
PubMed ID31181304

Physicochemical Properties

Residues13
SequenceFLGALWKVAKKVF
Molecular Weight1506.874
Grand Average of Hydropathy0.938
Isoelectric Point10.302
Charge at pH 7.42.55
Secondary StructureHelix: 0.538, Turn: 0.077, Sheet: 0.308
Instability Index7.854
Aromaticity0.231

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