Basic Information
| ID | DRAMP21460 |
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| Sequence | IHKFWRCRRRFCRWFKHI |
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| Length | 18 |
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| Name | PQ (De Novo Synthesis) |
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| Source | synthetic construct |
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| Activity | Antimicrobial, Antibacterial, Anti-Gram+, Anti-Gram- |
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| Pathogen | [Ref.30538681] Gram-positive bacteria:Staphylococcus aureus ATCC 29213(MIC=8μM), Staphylococcus aureus ATCC 43300(MIC=8μM), Staphylococcus epidermidis ATCC 12228(MIC=8μM), Streptococci faecalis ATCC 29212(MIC=16μM), Bacillus subtilis CMCC 63501(MIC=16μM);##Gram-negative bacteria:Escherichia coli ATCC 25922(MIC=16μM), Escherichia coli UB 1005(MIC=8μM), bacteria pyocyaneum ATCC 27853(MIC=8μM), Salmonella typhimurium ATCC 7731(MIC=8μM), Salmonella Pulloru C79-13(MIC=8μM) |
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| Hemolytic Activity | [Ref.30538681] MHC>128μM against human blood cells.The minimum hemolytic concentration (MHC) is defined as the peptide concentration resulting in 5% hemolysis. |
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| Cytotoxicity | [Ref.30538681] The cell viability of intestinal epithelial cells (IPEC-J2) induced by PQ is 68.2%, 68.6%, 66.8%,63.6%, 69.1%, 62.2%, 55.8% and 28.1% at peptide concentrations of 1, 2, 4, 8, 16, 32, 64 and 128 μM. |
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| N-terminal Modification | Free |
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| C-terminal Modification | Amidation |
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| Linear/Cyclic/Branched | Linear |
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| Uniprot |
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| PDB |
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| 3D View | |
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| PDB Download | Download PDB Predicted by Alphafold2 |
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| PubMed ID | 30538681 |
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