Basic Information

IDDRAMP21631
SequenceRLVRILVSKRPVAIKPYFRL
Length20
NameSLAY-P1
SourceSynthetic construct after SLAY screening and prediction
ActivityAntimicrobial, Antibacterial, Anti-Gram-
Pathogen[Ref.29307492] Gram-negative bacteria: E. coli W3110 (MBC = 2 μM), Acinetobacter baumannii 5075 (MBC ≤ 2 μM), Pseudomonas aeruginosa 14 (MBC ≤ 2 μM), E. coli conferring New Delhi metallo-beta-lactamase (MBC ≤ 2 μM).
Hemolytic Activity[Ref.29307492] The peptide showed 4.0% hemolysis against human red blood cells at 50 μM. PBS was uesd as a negative control and 1% triton was used as a positive control for 100% lysis.
CytotoxicityNo cytotoxicity information found
N-terminal ModificationFree
C-terminal ModificationFree
Linear/Cyclic/BranchedLinear
Uniprot
PDB
3D View
PDB DownloadDownload PDB Predicted by Alphafold2
PubMed ID29307492

Physicochemical Properties

Residues20
SequenceRLVRILVSKRPVAIKPYFRL
Molecular Weight2425.016
Grand Average of Hydropathy0.325
Isoelectric Point12
Charge at pH 7.45.55
Secondary StructureHelix: 0.500, Turn: 0.150, Sheet: 0.200
Instability Index46.675
Aromaticity0.1

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