Basic Information

IDDRAMP21637
SequenceIHRDQQHESFLDARPEPGLTE
Length21
NameSLAY-P7
SourceSynthetic construct after SLAY screening and prediction
ActivityAntimicrobial, Antibacterial, Anti-Gram-
Pathogen[Ref.29307492] Gram-negative bacteria: E. coli W3110 (MBC = 4 μM), Acinetobacter baumannii 5075 (MBC = 16 μM), Pseudomonas aeruginosa 14 (MBC = 4 μM), E. coli conferring New Delhi metallo-beta-lactamase (MBC = 4 μM).
Hemolytic Activity[Ref.29307492] The peptide showed 0.7% hemolysis against human red blood cells at 50 μM. PBS was uesd as a negative control and 1% triton was used as a positive control for 100% lysis.
CytotoxicityNo cytotoxicity information found
N-terminal ModificationFree
C-terminal ModificationFree
Linear/Cyclic/BranchedLinear
Uniprot
PDB
3D View
PDB DownloadDownload PDB Predicted by Alphafold2
PubMed ID29307492

Physicochemical Properties

Residues21
SequenceIHRDQQHESFLDARPEPGLTE
Molecular Weight2475.628
Grand Average of Hydropathy-1.348
Isoelectric Point5.011
Charge at pH 7.4-3.363
Secondary StructureHelix: 0.190, Turn: 0.190, Sheet: 0.286
Instability Index69.533
Aromaticity0.048

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