Basic Information

IDDRAMP21642
SequencePNDPDSPCVYRMPNARGCSI
Length20
NameSLAY-P12
SourceSynthetic construct after SLAY screening and prediction
ActivityAntimicrobial, Antibacterial, Anti-Gram-
Pathogen[Ref.29307492] Gram-negative bacteria: E. coli W3110 (MBC = 16 μM), Acinetobacter baumannii 5075 (MBC = 128 μM), Pseudomonas aeruginosa 14 (MBC = 16 μM), E. coli conferring New Delhi metallo-beta-lactamase (MBC = 16 μM).
Hemolytic Activity[Ref.29307492] The peptide showed 0.9% hemolysis against human red blood cells at 50 μM. PBS was uesd as a negative control and 1% triton was used as a positive control for 100% lysis.
CytotoxicityNo cytotoxicity information found
N-terminal ModificationFree
C-terminal ModificationFree
Linear/Cyclic/BranchedLinear
Uniprot
PDB
3D View
PDB DownloadDownload PDB Predicted by Alphafold2
PubMed ID29307492

Physicochemical Properties

Residues20
SequencePNDPDSPCVYRMPNARGCSI
Molecular Weight2192.455
Grand Average of Hydropathy-0.765
Isoelectric Point6.302
Charge at pH 7.4-0.149
Secondary StructureHelix: 0.150, Turn: 0.450, Sheet: 0.100
Instability Index35.29
Aromaticity0.05

Similar Structure Search

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