Basic Information

IDDRAMP21645
SequenceDATPHAALFFTVKDHTAGDN
Length20
NameSLAY-P15
SourceSynthetic construct after SLAY screening and prediction
ActivityAntimicrobial, Antibacterial, Anti-Gram-
Pathogen[Ref.29307492] Gram-negative bacteria: E. coli W3110 (MBC = 32 μM), Acinetobacter baumannii 5075 (MBC = 64 μM), Pseudomonas aeruginosa 14 (MBC = 32 μM), E. coli conferring New Delhi metallo-beta-lactamase (MBC = 64 μM).
Hemolytic Activity[Ref.29307492] The peptide showed 0.6% hemolysis against human red blood cells at 50 μM. PBS was uesd as a negative control and 1% triton was used as a positive control for 100% lysis.
CytotoxicityNo cytotoxicity information found
N-terminal ModificationFree
C-terminal ModificationFree
Linear/Cyclic/BranchedLinear
Uniprot
PDB
3D View
PDB DownloadDownload PDB Predicted by Alphafold2
PubMed ID29307492

Physicochemical Properties

Residues20
SequenceDATPHAALFFTVKDHTAGDN
Molecular Weight2128.257
Grand Average of Hydropathy-0.38
Isoelectric Point5.134
Charge at pH 7.4-2.37
Secondary StructureHelix: 0.200, Turn: 0.150, Sheet: 0.250
Instability Index4.29
Aromaticity0.1

Similar Structure Search

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