Basic Information

IDDRAMP21648
SequenceCNPLNGADRRTDSFPRFTVI
Length20
NameSLAY-P18
SourceSynthetic construct after SLAY screening and prediction
ActivityAntimicrobial, Antibacterial, Anti-Gram-
Pathogen[Ref.29307492] Gram-negative bacteria: E. coli W3110 (MBC = 128 μM), Acinetobacter baumannii 5075 (MBC > 128 μM), Pseudomonas aeruginosa 14 (MBC = 64 μM), E. coli conferring New Delhi metallo-beta-lactamase (MBC > 128 μM).
Hemolytic Activity[Ref.29307492] The peptide showed 1.7% hemolysis against human red blood cells at 50 μM. PBS was uesd as a negative control and 1% triton was used as a positive control for 100% lysis.
CytotoxicityNo cytotoxicity information found
N-terminal ModificationFree
C-terminal ModificationFree
Linear/Cyclic/BranchedLinear
Uniprot
PDB
3D View
PDB DownloadDownload PDB Predicted by Alphafold2
PubMed ID29307492

Physicochemical Properties

Residues20
SequenceCNPLNGADRRTDSFPRFTVI
Molecular Weight2279.534
Grand Average of Hydropathy-0.545
Isoelectric Point8.249
Charge at pH 7.40.534
Secondary StructureHelix: 0.250, Turn: 0.300, Sheet: 0.100
Instability Index32.415
Aromaticity0.1

Similar Structure Search

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