Basic Information

IDDRAMP29043
SequenceVDKPPYLPRPRPPRRIYNR
Length19
NameOncocin (variant of Oncopeltus antibacterial peptide 4)
SourceSynthetic construct (Oncocin is a variant of the 2 kDa Oncopeltus antibacterial peptide 4, which was originally isolated from oncopeltus fasciatus (milkweed bug))
ActivityAntimicrobial, Antibacterial, Anti-Gram-
Pathogen[Ref.20565063] Gram-negative pathogens: P.aeruginosa DSM3227 (MIC = 4 μg/mL), P. aeruginosa Walter (MIC = 8 μg/mL), P. aeruginosa ATCC27853 (MIC = 4 μg/mL), P. aeruginosa PAO1 (MIC = 2 μg/mL), P. aeruginosa 60811001 (MIC = 2 μg/mL), P. aeruginosa 60909001 (MIC = 2 μg/mL), P. aeruginosa 61118003 (MIC = 2 μg/mL), P. aeruginosa 70108001 (MIC = 4 μg/mL), E. coli 70329001 (MIC = 1 μg/mL), E. coli 70430001 (MIC = 1 μg/mL), E. coli 70419002 (MIC = 8 μg/mL), E. coli 70502001 (MIC = 1 μg/mL), E. coli Neumann (MIC = 2 μg/mL), E. coli 205024 (MIC = 4 μg/mL), E. coli 455/7 (MIC = 0.5 μg/mL), E. coli 8474 (MIC = 0.5 μg/mL), K. pneumoniae DSM681 (MIC = 0.25 μg/mL), K. pneumoniae 57 USA (MIC = 0.25 μg/mL), K. pneumoniae 63 (MIC = 8 μg/mL), K. pneumoniae 8085 (MIC = 0.5 μg/mL), K. pneumoniae ATCC12657 (0.5 μg/mL), K. pneumoniae ATCC27799 (MIC = 1 μg/mL), A. baumannii ICB14067 (MIC = 1 μg/mL), A. baumannii ICB14072 (MIC = 1 μg/mL), A. baumannii ICB14073 (MIC = 2 μg/mL), A. baumannii ICB9250 (MIC = 0.5 μg/mL), A. baumannii M17 (MIC = 1 μg/mL), E. cloacae 34654 (MIC = 0.25 μg/mL), E. cloacae Ha088 (MIC = 0.125 μg/mL), E. cloacae Ha089 (0.125 μg/mL), E. cloacae Ha185 (MIC = 0.5 μg/mL), E. cloacae Ha89 (MIC = 0.25 μg/mL), P. vulgaris ICB9081 (MIC = 4 μg/mL), P. vulgaris ICB9095 (MIC = 4 μg/mL), Stenotrophomonas ICB308054 (MIC = 32 μg/mL), Stenotrophomonas ICB7569 (MIC = 8 μg/mL), Stenotrophomonas ICB7789 (MIC = 32 μg/mL)
Hemolytic Activity[Ref.20565063]None of the tested peptides showed any hemolytic activity against human erythrocytes in the studied peptide concentration range up to 600 μg/mL.
Cytotoxicity[Ref.20565063] Oncocin showed no toxic effects on HeLa- or neuronal-cell-like differentiated SH-SY5Y cells at a peptide concentration of 600 μg/mL, which was about 100-fold above their MIC-values against E.coli BL21 AI.
N-terminal ModificationFree
C-terminal ModificationAmidation
Linear/Cyclic/BranchedLinear
Uniprot
PDB
3D View
PDB DownloadDownload PDB Predicted by Alphafold2
PubMed ID20565063

Physicochemical Properties

Residues19
SequenceVDKPPYLPRPRPPRRIYNR
Molecular Weight2390.79
Grand Average of Hydropathy-1.742
Isoelectric Point11.452
Charge at pH 7.44.516
Secondary StructureHelix: 0.263, Turn: 0.368, Sheet: 0.053
Instability Index62.053
Aromaticity0.105

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Candidates based on structure

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