| Pathogen | [Ref.32376222] Gram-positive bacteria: E. coli ESBL (LC99.9 = 3.75 μM in PT buffer, LC99.9 = 15 μM in PBS buffer); ##Gram-negative bacteria: S. aureus JAR060131 (LC99.9 = 3.75 μM in PT buffer, LC99.9 = 7.5-15 μM in PBS buffer, LC99.9 = 15-30 μM in 50% plasma).##Multi-drug resistant (MDR) gram-positive bacteria: E.faecium LUH10330 (LC99.9 = 1.6(1.6-3.2) μM in PBS buffer, LC99.9 =6.4 (3.2-6.4) μM in 50% plasma), S.aureus LUH14616 (LC99.9 = 3.2(3.2-6.4) μM in PBS buffer, LC99.9 = 12.8 (3.2-12.8) μM in 50% plasma).##Multi-drug resistant (MDR) and pan-drug resistant (PDR) gram-negative bacteria: K.pneumoniae LUH8995 (LC99.9 = 1.6(0.8-1.6) μM in PBS buffer, LC99.9 = 3.2 μM in 50% plasma), A.baumannii RUH875 (LC99.9 = 1.6(1.6-3.2) μM in PBS buffer, LC99.9 =6.4 (6.4-12.8) μM in 50% plasma), P.aeruginosa LUH15100 (LC99.9 = 4.8(3.2-6.4) μM in PBS buffer, LC99.9 > 204.8 μM in 50% plasma), E.cloacae LUH15114 (LC99.9 = 25.6 μM in PBS buffer, LC99.9 = 204.8 μM in 50% plasma)##Note: Results are expressed as the lethal concentration (LC) 99.9%, i.e. the lowest peptide concentration that resulted in >= 99.9% killing of bacteria after 2 h of incubation in PT buffer (10 mM phosphate buffer, pH 7.0, with 1% (v/v) TSB), phosphate buffered saline (PBS, pH 7.4) and in PBS with 50% (v/v) human plasma (one experiment, performed in duplicate). |
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