Basic Information
| ID | DRAMP29065 |
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| Sequence | KTMMQSGGTFGTFMAIGMGIR |
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| Length | 21 |
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| Name | AMPR-11(derived from Romo1) |
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| Source | Homo sapiens (Human) |
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| Activity | Antimicrobial, Antibacterial, Anti-Gram-, Anti-Gram+ |
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| Pathogen | [Ref.33291307] Gram-positive bacteria: S. aureus(MBC=100 μg/mL), B. subtilis(MBC=90 μg/mL), E. faecium(MBC=85 μg/mL), S. sindenensis(MBC=95 μg/mL), E. faecalis(MBC=85 μg/mL), S. pneumoniae(MBC=100 μg/mL)##Gram-negative bacteria: E. coli(MBC=85 μg/mL), P. aeruginosa(MBC=100 μg/mL), K. pneumoniae(MBC=100 μg/mL), A. baumannii(MBC=100 μg/mL), E. aerogenes(MBC=90 μg/mL)##Multi-drug resistant bacteria: Methicillin-resistant S. aureus(MBC=100 μg/mL), Carbapenem-resistant P. aeruginosa(MBC=110 μg/mL), Carbapenem-resistant A. baumannii(MBC=110 μg/mL), Carbapenem-resistant K. pneumoniae(MBC=100 μg/mL), Vancomycin-resistant S. aureus(MBC=120 μg/mL), Vancomycin-resistant E. faecium(MBC=100 μg/mL ) |
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| Hemolytic Activity | [Ref.33291307]At the concentration of 32 μg/mL, AMPR-11 induced a hemolysis of 20% on mouse red blood cells; At the concentration of 256 μg/mL, AMPR-11 induced a hemolysis of 23%. |
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| Cytotoxicity | [Ref.33291307] ①The cell viability of HeLa cells was 90%, 87%, 83% and 79% at the concentration of 32, 64, 128 and 256 μg/mL. ②The cell viability of HEK293 cells was 86%, 83%, 80% and 78% at the concentration of 32, 64, 128 and 256 μg/mL. ③The cell viability of HeLa cells was 89%, 86%, 83% and 80% at the concentration of 32, 64, 128 and 256 μg/mL. |
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| N-terminal Modification | Free |
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| C-terminal Modification | Free |
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| Linear/Cyclic/Branched | Linear |
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| Uniprot |
P60602 |
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| PDB |
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| 3D View | |
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| PDB Download | Download PDB Predicted by Alphafold2 |
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| PubMed ID | 32291307 |
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