Basic Information

IDDRAMP01066
SequencePVVDTTGNNPLQQQEEYYV
Length19
NameKunitz-type serine protease inhibitor 1 (Xb-KTI; Plants)
SourceXanthosoma sagittifolium (Elephant's ear) (Arum sagittifolium)
ActivityAntimicrobial, Antibacterial, Anti-Gram-
Pathogen[Ref.21520894]Gram-negative bacterium: Salmonella typhimurium ATCC 14028 (MIC=10 µM).
Hemolytic Activity[Ref.21520894] No hemolytic activity was observed for Xb-KTI. The peptide induced a hemolysis of 12% at the highest concentration of 250 μg/mL. Values(OD540) were normalized against 100% lysed erythrocytes (0.1% Triton X-100) and PDB (untreated control)
CytotoxicityNo cytotoxicity information found
N-terminal ModificationFree
C-terminal ModificationFree
Linear/Cyclic/BranchedLinear
Uniprot P86930
PDB
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PDB DownloadDownload PDB Predicted by Alphafold2
PubMed ID21520894

Physicochemical Properties

Residues19
SequencePVVDTTGNNPLQQQEEYYV
Molecular Weight2194.31
Grand Average of Hydropathy-1.011
Isoelectric Point4.05
Charge at pH 7.4-3.101
Secondary StructureHelix: 0.316, Turn: 0.263, Sheet: 0.158
Instability Index64.558
Aromaticity0.105

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