Basic Information
| ID | DRAMP01302 |
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| Sequence | FLSLIPHAINAVSTLVHHF |
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| Length | 19 |
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| Name | Phylloseptin-2 (PS-2; Frogs, amphibians, animals) |
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| Source | Phyllomedusa hypochondrialis (Orange-legged leaf frog) |
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| Activity | Antimicrobial, Antibacterial, Anti-Gram+, Anti-Gram-, Antifungal |
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| Pathogen | [Ref.18656510][ATCC Strains]: Gram-positive bacteria: S. aureus (MIC=15.1 µM);##Gram-negative bacteria: Escherichia coli (MIC=60.4 µM), Klebsiella pneumoniae (MIC=60.4 µM), Pseudomonas aeruginosa (MIC=60.4 µM);##[Wild Type]: Gram-positive bacteria: S. aureus (MIC=7.6 µM), S. agalactiae (MIC=1.9 µM);##Gram-negative bacteria: Pseudomonas aeruginosa (MIC=60.4 µM), A. calcoaceticus (MIC=3.7 µM);##Fungi: Candida albicans (MIC=15.1 µM). |
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| Hemolytic Activity | [Ref:15752569]0.1% hemolytic activity at 4 μM, 0.28% hemolytic activity at 4 μM, 0.7% hemolytic activity at 8 μM, 0.8% hemolytic activity at 16 μM, 1.05% hemolytic activity at 32 μM, 2.05% hemolytic activity at 64 μM against human red blood cells |
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| Cytotoxicity | [REf.15752569]No cytotoxicity information found##[Ref.18656510]No cytotoxicity information found |
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| N-terminal Modification | Free |
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| C-terminal Modification | Amidation |
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| Linear/Cyclic/Branched | Linear |
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| Uniprot |
P85881, P84567, Q0VZ43 |
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| PDB |
2JPY |
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| 3D View | |
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| PDB Download | Download PDB Predicted by Alphafold2 |
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| PubMed ID | 15752569, 18656510 |
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