Basic Information
| ID | DRAMP01347 |
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| Sequence | AIGSILGALAKGLPTLISWIKNR |
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| Length | 23 |
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| Name | Prepromelittin-related peptide (Frogs, amphibians, animals) |
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| Source | Rana tagoi (Tago frog) |
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| Activity | Antimicrobial, Antibacterial, Anti-Gram+, Anti-Gram-, Antifungal |
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| Pathogen | [Ref.12804591]Gram-positive bacterium: Staphylococcus aureus (MIC=3.5 µM);##Gram-negative bacterium: Escherichia coli (MIC=20 µM).##Yeast: Candida albicans (MIC=19 µM).##EL4 T-lymphoma cells (MIC=14 µM).##[Ref.27271216]Gram-positive bacteria : Staphylococcuss aureus (MIC=6.25 μM), Staphylococcus epidermidis (MIC=3.13 μM), Bacillus subtilis (MIC=3.13 μM);##Gram-negative bacteria : Escherichia coli (MIC=25 μM), Pseudomonas aeruginosa (MIC=12.5 μM), Klebsiella pneumoniae (MIC=12.5 μM) |
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| Hemolytic Activity | [Ref.27271216] 100% hemolysis at 20 μM against human red blood cells |
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| Cytotoxicity | [Ref.12804591]Display cytotoxic against L929 fibroblasts(LC50=20 μM);EL4 T-lymphoma cells(LC50=14 μM).##[Ref.27271216]L929 cells:Cell viability is approximately 10% at the concentration of 6.25 μM. |
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| N-terminal Modification | Free |
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| C-terminal Modification | Amidation |
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| Linear/Cyclic/Branched | Linear |
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| Uniprot |
A7BJK6 |
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| PDB |
6dst resolved by NMR (related PDB_ID) |
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| 3D View | |
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| PDB Download | Download PDB Predicted by Alphafold2 |
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| PubMed ID | 12804591, 17174009, 27271216 |
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