Basic Information

IDDRAMP01418
SequenceGLFGKILGVGKKVLCGLSGMC
Length21
NameNigrocin-2GRb (Frogs, amphibians, animals)
SourceRana grahami (Asian frog)
ActivityAntimicrobial, Antibacterial, Anti-Gram+, Anti-Gram-, Antifungal
Pathogen[Ref.16621155]Gram-positive bacterium: Staphylococcus aureus (MIC=12.5 µM);##Gram-negative bacterium: Escherichia coli (MIC=3 µM);##Yeast: Candida albicans (MIC=50 µM).
Hemolytic Activity[Ref:16621155] LC50=40 μM against human erythrocytes
CytotoxicityNo cytotoxicity information found
N-terminal ModificationFree
C-terminal ModificationCyclization (Cys15 and Cys21)
Linear/Cyclic/BranchedCyclic
Uniprot
PDB
3D View
PDB DownloadDownload PDB Predicted by Alphafold2
PubMed ID16621155

Physicochemical Properties

Residues21
SequenceGLFGKILGVGKKVLCGLSGMC
Molecular Weight2080.623
Grand Average of Hydropathy1.09
Isoelectric Point9.39
Charge at pH 7.42.501
Secondary StructureHelix: 0.381, Turn: 0.333, Sheet: 0.238
Instability Index-1.519
Aromaticity0.048

Similar Structure Search

Candidates based on structure

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