Basic Information

IDDRAMP01434
SequenceGILSGVLGMGKKIVCGLRGLC
Length21
NameNigrocin-1-OW4 (Frogs, amphibians, animals)
SourceOdorrana andersonii (Asian frog)
ActivityAntimicrobial, Antibacterial, Anti-Gram+, Anti-Gram-, Antifungal
Pathogen[Ref.22029824]Gram-negative bacteria: Escherichia coli ATCC 25922 (MIC=7.2 µg/ml), Bacillus pyocyaneus CMCCB 10104 (MIC=14.2 µg/ml);##Gram-positive bacterium: Staphylococcus aureus ATCC 25923 (MIC=3.6 µg/ml);##Yeast: Candida albicans ATCC 2002 (MIC=7.2 µg/ml).
Hemolytic Activity[Ref:22029824] Not found in the literature
CytotoxicityNo cytotoxicity information found
N-terminal ModificationFree
C-terminal ModificationCyclization (Cys15 and Cys21)
Linear/Cyclic/BranchedCyclic
Uniprot
PDB
3D View
PDB DownloadDownload PDB Predicted by Alphafold2
PubMed ID22029824

Physicochemical Properties

Residues21
SequenceGILSGVLGMGKKIVCGLRGLC
Molecular Weight2074.62
Grand Average of Hydropathy1.143
Isoelectric Point9.504
Charge at pH 7.42.503
Secondary StructureHelix: 0.381, Turn: 0.333, Sheet: 0.238
Instability Index7.652
Aromaticity0

Similar Structure Search

Candidates based on structure

Address: No.2699 Qianjin Street, Changchun City, China. Zip Code: 130012. 苏ICP备2021057230号-1.